Promethazine can be an H1 receptor blocking agent. Besides its antihistaminic action, it provides clinically useful sedative and antiemetic results.

Excessively large dosages of antihistamines, such as promethazine hydrochloride, in pediatric sufferers may possibly cause unexpected Dying (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of promethazine hydrochloride in pediatric individuals. In pediatric clients that are acutely sick connected with dehydration, There may be a heightened susceptibility to dystonias with the use of promethazine HCl.

The narcotic antagonist, naloxone hydrochloride, can be administered when sizeable respiratory depression occurs with promethazine and codeine; any depressant consequences of promethazine usually are not reversed with naloxone. Diazepam can be used to control convulsions. Stay clear of analeptics, which can cause convulsions. Acidosis and electrolyte losses should be corrected. An increase in temperature or pulmonary problems may well sign the necessity for establishment of antibiotic therapy.

Promethazine hydrochloride occurs as being a white to faint yellow, nearly odorless, crystalline powder which gradually oxidizes and turns blue on prolonged publicity to air.

Steer clear of using Promethazine HCl and Codeine Phosphate Oral Solution in adolescents twelve to eighteen several years of age who produce other possibility variables that will enhance their sensitivity for the respiratory depressant outcomes of codeine.

Focus–Adverse Response Associations There's a partnership amongst escalating codeine plasma concentration and increasing frequency of dose- similar opioid adverse reactions for instance nausea, vomiting, CNS results, and respiratory depression.

Anaphylactic reactions, as adjunctive therapy to epinephrine and other conventional measures, once the acute manifestations are managed.

For example, several documented instances of Demise happened from the submit-operative period pursuing tonsillectomy and/or adenoidectomy, and several of the children experienced proof of getting extremely-swift metabolizers of codeine. In addition, young children with obstructive sleep apnea who will be handled with codeine for write-up-tonsillectomy and/or adenoidectomy agony could be notably delicate to its respiratory depressant impact. Because of the risk of everyday living-threatening respiratory depression and Loss of life:

Promethazine is really an H1 receptor blocking agent. In addition to its antihistaminic action, it provides clinically handy sedative and antiemetic consequences.

Excessively significant dosages of antihistamines, together with Promethazine HCl Oral Solution, in pediatric patients may possibly induce unexpected Dying (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of Promethazine in pediatric clients. In pediatric individuals who are acutely sick linked to dehydration, There may be an elevated susceptibility to dystonias with the use of Promethazine HCl.

Postmarketing scenarios of respiratory depression, which include fatalities, have already been claimed with use of promethazine hydrochloride in pediatric clients lower click here than two years of age. An array of pounds-primarily based doses of promethazine hydrochloride have resulted in respiratory melancholy in these people.

Stimulation might be apparent, particularly in small children and geriatric patients. Convulsions may perhaps rarely arise. A paradoxical-style reaction continues to be reported in young children getting one doses of seventy five mg to a hundred twenty five mg orally, characterized by hyperexcitability and nightmares.

The concomitant usage of Promethazine HCl and Codeine Phosphate Oral Remedy with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor might end in decrease codeine ranges, increased norcodeine levels, and less metabolism by means of 2D6 with resultant lower morphine amounts.

Promethazine Indicators and signs and symptoms of overdosage with promethazine range from moderate depression of the central anxious program and cardiovascular program to profound hypotension, respiratory depression, unconsciousness and sudden Demise.